原発巣とリンパ節転移巣から樹立した舌扁平上皮癌細胞における発現遺伝子の比較 : 転移関連遺伝子同定の試み [in Japanese] Comparison of genes expressed in cell lines derived from the primary lesion and lymph node metastasis of a squamous cell carcinoma arising in the tongue : A trial designed to identify metastasis-related genes [in Japanese]
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We established a pair of cell lines derived from the primary lesion (KK-p) and lymph node metastasis (KK-m) of a tongue carcinoma. We compared the profiles of genes expressed in KK-p and KK-m cells by microarray analysis. Seven genes were highly expressed and 26 were poorly expressed in KK-m cells as compared with KK-p cells. The expression ratios of 14 genes were confirmed by real time RT PCR, and the results were similar to those of the microarray analysis. These results suggested that some of the genes identified in this study may be new metastasis-related genes.
- Journal of Oral Surgery Society of Japan
Journal of Oral Surgery Society of Japan 51(10), 482-488, 2005-10-20
Japanese Society of Oral and Maxillofacial Surgeons