原発巣とリンパ節転移巣から樹立した舌扁平上皮癌細胞における発現遺伝子の比較 : 転移関連遺伝子同定の試み Comparison of genes expressed in cell lines derived from the primary lesion and lymph node metastasis of a squamous cell carcinoma arising in the tongue : A trial designed to identify metastasis-related genes

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著者

    • 信森 剛 NOBUMORI Takeshi
    • 広島大学大学院医歯薬学総合研究科展開医科学専攻顎口腔頚部医科学講座口腔外科学教室 Department of Oral and Maxillofacial Surgery, Programs for Applied Biomedicine, Division of Cervico-Gnathostmatology, Graduate School of Biomedical Sciences, Hiroshima University
    • 瀧 雅行 TAKI Masayuki
    • 広島大学大学院医歯薬学総合研究科展開医科学専攻顎口腔頚部医科学講座口腔外科学教室 Department of Oral and Maxillofacial Surgery, Programs for Applied Biomedicine, Division of Cervico-Gnathostmatology, Graduate School of Biomedical Sciences, Hiroshima University
    • 東川 晃一郎 [他] HIGASHIKAWA Koichiro
    • 広島大学大学院医歯薬学総合研究科展開医科学専攻顎口腔頚部医科学講座口腔外科学教室 Department of Oral and Maxillofacial Surgery, Programs for Applied Biomedicine, Division of Cervico-Gnathostmatology, Graduate School of Biomedical Sciences, Hiroshima University
    • 小野 重弘 ONO Shigehiro
    • 広島大学大学院医歯薬学総合研究科展開医科学専攻顎口腔頚部医科学講座口腔外科学教室 Department of Oral and Maxillofacial Surgery, Programs for Applied Biomedicine, Division of Cervico-Gnathostmatology, Graduate School of Biomedical Sciences, Hiroshima University
    • 重石 英生 SHIGEISHI Hideo
    • 広島大学大学院医歯薬学総合研究科展開医科学専攻顎口腔頚部医科学講座口腔外科学教室 Department of Oral and Maxillofacial Surgery, Programs for Applied Biomedicine, Division of Cervico-Gnathostmatology, Graduate School of Biomedical Sciences, Hiroshima University
    • 米田 進吾 YONEDA Shingo
    • 広島大学大学院医歯薬学総合研究科展開医科学専攻顎口腔頚部医科学講座口腔外科学教室 Department of Oral and Maxillofacial Surgery, Programs for Applied Biomedicine, Division of Cervico-Gnathostmatology, Graduate School of Biomedical Sciences, Hiroshima University
    • 二宮 嘉昭 NINOMIYA Yoshiaki
    • 広島大学大学院医歯薬学総合研究科展開医科学専攻顎口腔頚部医科学講座口腔外科学教室 Department of Oral and Maxillofacial Surgery, Programs for Applied Biomedicine, Division of Cervico-Gnathostmatology, Graduate School of Biomedical Sciences, Hiroshima University
    • 杉山 勝 SUGIYAMA Masaru
    • 広島大学歯学部口腔保健学科口腔保健衛生学講座社会歯科保健学分野 Department of Oral Health Research, Division of Oral Health Science, Institute of Oral Health Science, Faculty of Dentistry, Hiroshima University
    • 鎌田 伸之 KAMATA Nobuyuki
    • 広島大学大学院医歯薬学総合研究科展開医科学専攻顎口腔頚部医科学講座口腔外科学教室 Department of Oral and Maxillofacial Surgery, Programs for Applied Biomedicine, Division of Cervico-Gnathostmatology, Graduate School of Biomedical Sciences, Hiroshima University

抄録

We established a pair of cell lines derived from the primary lesion (KK-p) and lymph node metastasis (KK-m) of a tongue carcinoma. We compared the profiles of genes expressed in KK-p and KK-m cells by microarray analysis. Seven genes were highly expressed and 26 were poorly expressed in KK-m cells as compared with KK-p cells. The expression ratios of 14 genes were confirmed by real time RT PCR, and the results were similar to those of the microarray analysis. These results suggested that some of the genes identified in this study may be new metastasis-related genes.

収録刊行物

  • 日本口腔外科学会雑誌  

    日本口腔外科学会雑誌 51(10), 482-488, 2005-10-20 

    Japanese Society of Oral and Maxillofacial Surgeons

参考文献:  32件

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各種コード

  • NII論文ID(NAID)
    10018954374
  • NII書誌ID(NCID)
    AN00189163
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    00215163
  • NDL 記事登録ID
    7708717
  • NDL 雑誌分類
    ZS44(科学技術--医学--歯科学・口腔外科学)
  • NDL 請求記号
    Z19-145
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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