ヒト口腔扁平上皮癌における第2番染色体長腕上のヘテロ接合性消失とマイクロサテライト不安定性について Loss of heterozygosity and microsatellite instability on the long arm of chromosome 2 in human oral squamous cell carcinoma

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Frequent allelic imbalances, including loss of heterozygosity (LOH) and microsatellite instability (MSI), have been found on the long arm of chromosome 2 (2q) in several types of human cancer. This study was designed to identify the tumor suppressor locus (or loci) associated with oral squamous cell carcinoma (SCC) on 2q. To better understand the details of genetic alterations on 2q, we performed polymerase chainreaction analysis of microsatellite polymorphisms corresponding to 10 loci on this chromosome. We identified a novel tumor suppressor locus in this region in primary oral SCCs. To further determine the role of 2q deletions in oral carcinogenesis, 19 oral SCCs (19 sets of primary and corresponding normal tissues) were examined for allelic imbalances (LOH or MSI) on 2q, using ten microsatellite markers. Among these 19 patients, 11 (57.9%) showed LOH at one or more loci. Deletion mapping of these tumors revealed four discrete, commonly deleted regions on the chromosome arm. Furthermore, we detected MSI in 4 of the patients (21.1 %).We compared our results with clinicopathologic features. A number of sites with LOH on 2q were detected in early stage lesions, and the frequency of LOH was slightly but not significantly higher in later clinical stages. Our results suggest that allelic imbalances on 2q are involved in the development of oral SCC and that one or more putative tumor suppressor genes contributing to the pathogenesis of this disease are present on 2q.

収録刊行物

  • 日本口腔外科学会雑誌  

    日本口腔外科学会雑誌 51(8), 374-381, 2005-08-20 

    Japanese Society of Oral and Maxillofacial Surgeons

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各種コード

  • NII論文ID(NAID)
    10018954655
  • NII書誌ID(NCID)
    AN00189163
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    00215163
  • NDL 記事登録ID
    7459747
  • NDL 雑誌分類
    ZS44(科学技術--医学--歯科学・口腔外科学)
  • NDL 請求記号
    Z19-145
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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