肺癌に対するゲフィチニブ(イレッサ^【○!R】)投与中に座瘡様皮疹を呈した6例  [in Japanese] Acneiform Follicular Eruption in Patients Treated with Gefitinib : Report of Six Cases  [in Japanese]

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Author(s)

Abstract

肺癌治療のために選択的上皮成長因子受容体チロシンキナーゼ阻害剤であるゲフィチニブ(イレッサ<sup>®</sup>)を1日あたり250mg内服投与中に, ざ瘡様皮疹を生じた6例を経験したので報告する。程度は様々であったが全例ゲフィチニブ内服中に毛孔一致性粟粒大の紅色小丘疹, 小膿疱が主に顔面, 前胸部, 背部などに出現した。6例中1例は皮膚生検を施行し, 病理組織学的に真皮上層の毛嚢周囲にリンパ球を主体とした炎症性細胞の浸潤を認めた。

Gefitinib (Iressa<sup>®</sup>) is a new anticancer agent against lung cancer that acts by inhibiting signal transduction of the growth factor receptor. We describe six patients receiving gefitinib (250mg/day) who developed an acne-like eruption consisting of follicular papules and pustules on their faces, chests and/or backs. A histopathological examination of one patient revealed an inflammatory cell infiltration around the hair follicles.

Journal

  • The Nishinihon Jourrnal of Dermatology  

    The Nishinihon Jourrnal of Dermatology 66(6), 599-601, 2004-12-01 

    Western Division of Japanese Dermatological Association

References:  7

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Codes

  • NII Article ID (NAID)
    10018999329
  • NII NACSIS-CAT ID (NCID)
    AN00183881
  • Text Lang
    JPN
  • Article Type
    NOT
  • ISSN
    03869784
  • NDL Article ID
    7295773
  • NDL Source Classification
    ZS39(科学技術--医学--皮膚科学・泌尿器科学)
  • NDL Call No.
    Z19-69
  • Data Source
    CJP  NDL  J-STAGE 
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