A Case of Toxic Epidermal Necrolysis due to Acetaminophen

DOI Web Site 21 References
  • TAKEUCHI Yoshiharu
    Department of Anatomy, Biology and Medicine (Dermatology), Faculty of Medicine, Oita University
  • KATAGIRI Kazumoto
    Department of Anatomy, Biology and Medicine (Dermatology), Faculty of Medicine, Oita University
  • HATANO Yutaka
    Department of Anatomy, Biology and Medicine (Dermatology), Faculty of Medicine, Oita University
  • FUJIWARA Sakuhei
    Department of Anatomy, Biology and Medicine (Dermatology), Faculty of Medicine, Oita University

Bibliographic Information

Other Title
  • パッチテストが陽性であったPL<sup>®</sup>顆粒中のアセトアミノフェンによるTEN型薬疹の1例

Search this article

Abstract

A 43-year-old Japanese female took cefcapene and a medicine for cold that was composed of several ingredients, including acetaminophen. On the following day, edematous erythema and bullae on her trunk and limbs, erosion in the mucous membranes of lips and conjunctiva, and high fever developed. A biopsy specimen taken from her right forearm revealed subepidermal bulla with scattered necrotic keratinocytes in the epidermis, exocytosis of mononuclear cells and focal hydropic degeneration. Eruption subsided rapidly and erosions healed within 25 days after administration of systemic corticosteroid therapy, leaving pigmentation. One month after discontinuation of therapy, a patch test was performed using acetaminophen and other ingredients that were in the cold medicine, such as salicylamido, promethazine methylenedisalicylic acid, and caffeine anhydride. Papules and erythema were observed at the site at which acetaminophen had been applied. Although a drug lymphocyte stimulation test performed during corticosteroid therapy using acetaminophen was negative, we made the diagnosis of toxic epidermal necrolysis due to acetaminophen.

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 66 (4), 385-388, 2004

    Western Division of Japanese Dermatological Association

References(21)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top