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- Yamaguchi Shinya
- Marukin Bio, Inc.
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- Ohnishi Jun
- Marukin Bio, Inc.
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- Maru Isafumi
- Marukin Bio, Inc.
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- Ohta Yasuhiro
- Marukin Bio, Inc.
書誌事項
- タイトル別名
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- Simple and Large-Scale Production of N-Acetylneuraminic Acid and N-Acetyl-D-Mannosamine
- N アセチルノイラミンサン オヨビ N アセチル D マンノサミン ノ カンイ タイリョウ セイゾウホウ ガン エイブン
この論文をさがす
抄録
We have developed novel methods for large-scale production of N-acetylneuraminic acid (Neu5Ac) and N-acetyl-D-mannosamine (ManNAc). For the production of Neu5Ac, we constructed two methods (chemoenzymatic synthesis and enzymation) from N-acetyl-D-glucosamine (GlcNAc) and pyruvate as substrates with N-acetylneuraminate lyase (Neu5Ac lyase) as a catalyst. In the epimerization from GlcNAc to ManNAc, one of them was carried out by the alkaline condition, and the other was by N-acyl-D-glucosamine 2-epimerase. On the other hand, we also established a novel method for the ManNAc production from Neu5Ac. It was characterized that Neu5Ac cleaved to ManNAc and pyruvate by Neu5Ac lyase on the anion exchange resin for accomplishing the complete cleavage of Neu5Ac. These methods are simple and easy, and fit for the large-scale production of Neu5Ac and ManNAc in industry, so that they may be used as raw ingredients for pharmaceuticals.
収録刊行物
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- Trends in Glycoscience and Glycotechnology
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Trends in Glycoscience and Glycotechnology 18 (102), 245-252, 2006
FCCA(Forum: Carbohydrates Coming of Age)
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キーワード
詳細情報
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- CRID
- 1390001204369757056
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- NII論文ID
- 10019281905
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- NII書誌ID
- AA10995236
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- COI
- 1:CAS:528:DC%2BD28XhtVyqt7bI
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- ISSN
- 18832113
- 09157352
- http://id.crossref.org/issn/09157352
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- NDL書誌ID
- 8076626
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可