Promotion of Thyroid Tumors in F344 Male Rats Given a Low Iodine Diet after Treatment with N-Methyl-NNitrosourea in Their Drinking Water.

• 後藤 孝彦

  Department of Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima University

• 渡辺 敦光

  Department of Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima University

• 谷崎 みどり

  Department of Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima University

• 酒井 葉子

  Department of Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima University

• 藤本 成明

  Department of Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima University

• 伊藤 明弘

  Department of Cancer Research, Research Institute for Radiation Biology and Medicine, Hiroshima University

抄録

The present study was designed to examine the effects of a low iodine diet (LID) on tumorigenesis in F344 rats treated with N-methyl-N-nitrosourea (MNU). Four-week-old male F344 rats were exposed to 100 ppm MNU in their drinking water for 15 weeks. Thereafter Group 2 animals received a low iodine diet LID while Group 1 received no further treatment after MNU. Non-carcinogen control animals received the LID without prior initiation (Group 3). At sacrifice, 36 weeks after starting MNU administration, nerve tumors were present in 16 of 20 (80%) animalls, and 19 of 32 (59%) in Groups 1 and 2, respectively, mostbeing malignant schwannomas. Thymic lymphomas appeared in 7 of 20 (35%) rats in Group I and 15 of 32 (47%) in Group 2, and also gastric tumors were present in 6 of 20 (30%) in Group I and 10 of 32 (31) in Group 2. There were no significant intergroups differences regarding these lesions. However, the incidence of thyroid carcinomas in Group 2 was significantly higher than that in Group I (P<0.01). Also cumulative incidence curves indicated a significantly earlier appearancein Group 2 and the number of rats bearing 3 different tumors was significantly increased in this group (P<0.01). Moreovar, administration of the LID was itself associated with a small incidence of thyroid lesions.

収録刊行物

• Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃ　Ｐａｔｈｏｌｏｇｙ

  Ｊｏｕｒｎａｌ　ｏｆ　Ｔｏｘｉｃｏｌｏｇｉｃ　Ｐａｔｈｏｌｏｇｙ 9 (2), 191-197, 1996

  日本毒性病理学会

キーワード

• MNU
• Thyroid tumors
• Low iodine diet
• F344 rat

詳細情報

• CRID: 1390001204415712256
• NII論文ID: 10019304499
• NII書誌ID: AA12022786
• DOI: 10.1293/tox.9.191
• ISSN: 1881915X
• ISSN: 09149198
• Web Site: http://www.jstage.jst.go.jp/article/tox1988/9/2/9_2_191/_pdf
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可