Effect of Colestimide Therapy for Glycemic Control in Type 2 Diabetes Mellitus with Hypercholesterolemia
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- YAMAKAWA Tadashi
- Department of Endocrinology and Diabetes, Yokohama City University Medical Center
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- TAKANO Tatsuro
- Department of Endocrinology and Diabetes, Yokohama City University Medical Center
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- UTSUNOMIYA Hirotoshi
- Department of Pathology, Wakayama Medical University
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- KADONOSONO Kazuaki
- Department of Ophthalmology, Yokohama City University Medical Center
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- OKAMURA Atushi
- Department of Endocrinology and Diabetes, Yokohama City University Medical Center
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抄録
Colestimide is a new anion-exchange resin used to lower serum cholesterol in Japan. Because of its excellent compliance, colestimide can replace cholestyramine. To clarify the effect of colestimide on glycemic controls, colestimide (3 g/day) or pravastatin (10 mg) was given orally to patients with type 2 diabetes treated with oral hypoglycemic agents or insulin who had low-density lipoprotein (LDL) cholesterol levels exceeding 3.6 mmol/l. In the colestimide groups, fasting plasma glucose concentrations had decreased significantly from 8.5 ± 1.4 to 7.7 ± 1.5 mmol/l at 3 months (P<0.05), as had glycated hemoglobin (HbA1c) from 7.7 ± 0.7% to 6.8 ± 0.5%, for an 8% reduction (P<0.01). Fasting plasma glucose and HbA1c did not change in the pravastatin group. Total cholesterol and LDL-cholesterol decreased significantly (P<0.01) with either medication, with similar reduction rates for both drugs. Doses of oral hypoglycemic agents and insulin did not change during the study, and body weight remained stable. Considering that patients with type 2 diabetes often have hyperlipidemia, colestimide therapy may have a clinically useful dual action in such patients.<br>
収録刊行物
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- Endocrine Journal
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Endocrine Journal 54 (1), 53-58, 2007
一般社団法人 日本内分泌学会
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詳細情報 詳細情報について
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- CRID
- 1390282681275838208
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- NII論文ID
- 10019479257
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- NII書誌ID
- AA10901436
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- COI
- 1:STN:280:DC%2BD2s7nvFSlsQ%3D%3D
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- ISSN
- 13484540
- 09188959
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- PubMed
- 17102570
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
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- 使用不可