Comparison of Glycated Albumin (GA) and Glycated Hemoglobin (HbA1c) in Type 2 Diabetic Patients: Usefulness of GA for Evaluation of Short-term Changes in Glycemic Control
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- TAKAHASHI Satomi
- Metabolism and Endocrinology, Department of Medicine, Juntendo University School of Medicine
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- UCHINO Hiroshi
- Metabolism and Endocrinology, Department of Medicine, Juntendo University School of Medicine
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- SHIMIZU Tomoaki
- Metabolism and Endocrinology, Department of Medicine, Juntendo University School of Medicine
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- KANAZAWA Akio
- Metabolism and Endocrinology, Department of Medicine, Juntendo University School of Medicine
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- TAMURA Yoshifumi
- Metabolism and Endocrinology, Department of Medicine, Juntendo University School of Medicine
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- SAKAI Ken
- Metabolism and Endocrinology, Department of Medicine, Juntendo University School of Medicine
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- WATADA Hirotaka
- Metabolism and Endocrinology, Department of Medicine, Juntendo University School of Medicine
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- HIROSE Takahisa
- Metabolism and Endocrinology, Department of Medicine, Juntendo University School of Medicine
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- KAWAMORI Ryuzo
- Metabolism and Endocrinology, Department of Medicine, Juntendo University School of Medicine
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- TANAKA Yasushi
- Metabolism and Endocrinology, Department of Medicine, Juntendo University School of Medicine Metabolism and Endocrinology, Department of Medicine, St. Marianna University School of Medicine
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We studied the cross-sectional relationship between GA and HbA1c in 142 type 2 diabetic patients who had an HbA1c level <7.5% for at least one year without fluctuation by more than 0.5%. We also followed the changes of GA and HbA1c in 18 type 2 diabetic patients for 16 weeks as they progressed from untreated severe hyperglycemia (HbA1c≥9.0%) to good glycemic control (HbA1c≤6.5%) by intensive insulin treatment. The annual mean levels of GA and HbA1c in the stably controlled patients showed a weak, but significant, correlation (r = 0.23, p<0.001) in the 142 diabetic patients. However, the GA/HbA1c ratio ranged widely from 2.0 to 4.0 showing a normal distribution (2.9 ± 0.34, M ± SE), although patients with conditions affecting albumin turnover or RBC lifespan were excluded from the study. The GA/HbA1c ratio was significantly higher when patients were in hyperglycemic than when glycemic control was good (3.5 ± 0.15 vs. 2.9 ± 0.07, M ± SE, p<0.01). GA decreased more rapidly than HbA1c during intensive insulin therapy, but the percent reduction of HbA1c eventually corresponded with that of GA by 16 weeks after the start of treatment. These results demonstrate that, although unknown influences on GA or HbA1c may exist, GA may be a useful marker for monitoring short-term variations of glycemic control during treatment of diabetic patients.<br>
収録刊行物
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- Endocrine Journal
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Endocrine Journal 54 (1), 139-144, 2007
一般社団法人 日本内分泌学会
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詳細情報 詳細情報について
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- CRID
- 1390282681275918720
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- NII論文ID
- 10019479652
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- NII書誌ID
- AA10901436
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- COI
- 1:STN:280:DC%2BD2s7nvFWkug%3D%3D
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- ISSN
- 13484540
- 09188959
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- PubMed
- 17159300
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- PubMed
- CiNii Articles
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- 使用不可