Recognition of bacterial compounds by aortic endothelial cells activates Weibel-Palade body exocytosis

• Into Takeshi

  Department of Oral Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology

• Matsushita Kenji

  Department of Oral Disease Research, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology

抄録

The endothelial cell-specific granule Weibel-Palade body releases vasoactive substances capable of modulating vascular inflammation, thrombosis and atherogenesis. Pathogen recognition by endothelial Toll-like receptors (TLRs) is thought to play a crucial role in promotion of vascular inflammatory responses. However, the molecular basis for the early-phase responses of endothelial cells to pathogens has not been fully elucidated. We found that human aortic endothelial cells respond to several TLR ligands, including bacterial lipoteichoic acids and lipopeptides, but not lipopolysaccharides, to induce Weibel-Palade body exocytosis, accompanied by release of the storage component von Willebrand factor. In this mini-review, we briefly describe a novel function of endothelial TLRs and discuss its implications in aortic inflammation or atherogenesis.

収録刊行物

• Inflammation and Regeneration

  Inflammation and Regeneration 27 (2), 112-116, 2007

  一般社団法人 日本炎症・再生医学会

キーワード

• endothelial cell
• exocytosis
• Toll-like receptor
• inflammation

詳細情報

• CRID: 1390282680233448576
• NII論文ID: 10019482581
• NII書誌ID: AA11508953
• DOI: 10.2492/inflammregen.27.112
• ISSN: 18808190
• ISSN: 18809693
• NDL書誌ID: 8778690
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8778690
• Web Site: https://search.jamas.or.jp/link/ui/2007265407
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可