Invited review article: Chemical control of biological activity and biodistribution of metal compounds: drug design of metal complexes with biological activity and target-specific biodistribution
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- Saji Hideo
- Department of Patho-functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University
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- Ogawa Kazuma
- Central Institute of Radioisotopes Science, Division of Tracer Kinetics, Advanced Science Research Center, Kanazawa University
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- Kitamura Youji
- Graduate School of Medicine and Dentistry and Pharmaceutical Sciences, Okayama University
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- Kubota-Akizawa Megumi
- Department of Patho-functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University
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- Kawashima Hidekazu
- Department of Patho-functional Bioanalysis, Graduate School of Pharmaceutical Sciences, Kyoto University
書誌事項
- タイトル別名
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- Chemical Control of Biological Activity and Biodistribution of Metal Compounds: Drug Design of Metal Complexes with Biological Activity and Target-Specific Biodistribution
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抄録
The development of metallic compounds for the diagnosis and therapy of diseases has been expected to open a new field of medicinal science. These compounds are required to exhibit biological activity and a specific localization to the target tissue. These demands constitute a great challenge on the rational design of metallic compounds and we have proposed two approaches, a pendant approach and an integrated approach in order to achieve this purpose. The pendant approach involves designing a biologically active compound by the attachment of a chelating group for binding the metal ion to a mother compound without the effect on the inherent biospecificity of the mother compound. A typical example of the pendant approach is bifunctional radiopharmaceuticals used for nuclear medical diagnosis and internal radiotherapy. The integrated approach involves designing a metallic compound with a biologically activity and physicochemical properties suitable for target-specific delivery by coordination to a mother compound with metal ion.<br> This review will describe our recent progress in research on a bifunctional radiopharamceutical labeled with metallic radionuclides, Rhenium-186 for therapy of painful bone metastases as an example of the pendant approach and a lipophilic zinc complex with protective effect against ischemic neuronal injury as an example of the integrated approach.
収録刊行物
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- Biomedical Research on Trace Elements
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Biomedical Research on Trace Elements 18 (3), 255-263, 2007
日本微量元素学会
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詳細情報 詳細情報について
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- CRID
- 1390001204367179648
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- NII論文ID
- 130004456829
- 10019766080
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- NII書誌ID
- AN10423256
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- ISSN
- 18801404
- 0916717X
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- NDL書誌ID
- 8982104
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可