Immunolocalization of Steroidogenic Enzymes in Equine Fetal Adrenal Glands During Mid-Late Gestation

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  • WENG Qiang
    College of Biological Science and Technology, Beijing Forestry University Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology
  • TANAKA Yumiko
    Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology Department of Basic Veterinary Science, United Graduate School of Veterinary Sciences, Gifu University
  • TANIYAMA Hiroyuki
    Department of Veterinary Pathology, Rakuno Gakuen University
  • TSUNODA Nobuo
    Shadai Corporation
  • NAMBO Yasuo
    Hidaka Training Research Center, Japan Racing Association
  • WATANABE Gen
    Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology Department of Basic Veterinary Science, United Graduate School of Veterinary Sciences, Gifu University
  • TAYA Kazuyoshi
    Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology Department of Basic Veterinary Science, United Graduate School of Veterinary Sciences, Gifu University

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To elucidate the relationship between steroidogenic hormones and developing adrenal glands, we investigated the immunolocalization of steroidogenic enzymes in equine fetal adrenal glands during mid-late gestation. Fetal adrenal glands were obtained from three horses at 217, 225 and 235 days of gestation. Steroidogenic enzymes were immunolocalized using polyclonal antisera raised against bovine adrenal cholesterol side-chain cleavage cytochrome P450 (P450scc), human placental 3β-hydroxysteroid dehydrogenase (3βHSD), porcine testicular 17α-hydroxylase cytochrome P450 (P450c17) and human placental aromatase cytochrome P450 (P450arom). Histologically, cortex and medulla cells were clearly observed in the three fetal adrenal gland tissue samples. P450scc and P450c17 were identified in cortex cells close to medulla cells and in some medulla cells in the fetal adrenal glands. P450arom was present in both cortex and medulla cells in the fetal adrenal glands. However, 3βHSD was not found in any of the equine fetal adrenal gland tissue samples. These results suggest that equine fetal adrenal glands have the ability to synthesize androgen and estrogen, which may play an important physiological role in the development of equine fetal adrenal glands.<br>

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