Spontaneous adenocarcinoma immunoreactive to cyclooxygenase-2 and transforming growth factor-β1 in the buccal salivary gland of a Richardson's ground squirrel (Spermophilus richardsonii)

• YAMATE Jyoji

  Laboratory of Veterinary Pathology, Life and Environmental Sciences, Osaka Prefecture University

• YAMAMOTO Emi

  Laboratory of Veterinary Pathology, Life and Environmental Sciences, Osaka Prefecture University

• NABE Mikoto

  Laboratory of Veterinary Pathology, Life and Environmental Sciences, Osaka Prefecture University

• KUWAMURA Mitsuru

  Laboratory of Veterinary Pathology, Life and Environmental Sciences, Osaka Prefecture University

• FUJITA Daisuke

  Kitasuma Animal Hospital

• SASAI Hiroshi

  Kitasuma Animal Hospital

書誌事項

タイトル別名

• Spontaneous Adenocarcinoma Immunoreactive to Cyclooxygenase-2 and Transforming Growth Factor-.BETA.1 in the Buccal Salivary Gland of a Richardson's Ground Squirrel (Spermophilus richardsonii)
• Spontaneous adenocarcinoma immunoreactive to cyclooxygenase 2 and transforming growth factor b 1 in the buccal salivary gland of a Richardson s ground squirrel Spermophilus richardsonii

抄録

The ground squirrel is used as an experimental animal because of its unique biological nature. A 3-year-old female Richardson's ground squirrel developed a mass, 1.5 cm in diameter, in the buccal mucosa. The mass consisted of neoplastic epithelial cells showing acinar, ductular, intraductal papillary, solid, and lobular growth patterns; the cells were immunoreactive to cytokeratin, cyclooxygenase-2 (a marker of malignancy) and TGF-β1. After resection, the tumor recurred with increased area having a solid or lobular pattern with little differentiation. This tumor was diagnosed as an adenocarcinoma arising from the buccal gland, the first case reported in the ground squirrel. A prominent desmoplastic reaction was present. The interstitial cells reacted to α-smooth muscle actin and vimentin, indicating a myofibroblastic nature, presumably induced by epithelial TGF-β1. <br>

収録刊行物

• Experimental Animals

  Experimental Animals 56 (5), 379-384, 2007

  公益社団法人 日本実験動物学会

キーワード

• Ground squirrel
• myofibroblast
• salivary gland carcinoma

詳細情報

• CRID: 1390282680023437824
• NII論文ID: 10019776750
• NII書誌ID: AA11032321
• DOI: 10.1538/expanim.56.379
• ISSN: 18817122
• ISSN: 00075124
• ISSN: 13411357
• NDL書誌ID: 8949717
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8949717
• Web Site: http://www.jstage.jst.go.jp/article/expanim/56/5/56_5_379/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008115354
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可