Testicular Development in Growth-Retarded Mice

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  • KOBAYASHI Kenichi
    National Institute of Occupational Safety and Health
  • KUBOTA Hisayo
    National Institute of Occupational Safety and Health
  • SAEGUSA Junzo
    National Institute of Occupational Safety and Health Okinawa Institute of Science and Technology

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Abstract

To assess delayed fertility in male growth-retarded (grt) mice with congenital primary hypothyroidism, their testes were chronologically examined. The testicular weight in grt mice was significantly lower than age-matched normal mice until 8 weeks but was comparable at 13 and 26 weeks. While normal mice had mature sperm cells in both testes and epididymides at 5 weeks, age-matched grt mice did not. The size of the seminiferous tubules in testes of grt mice was smaller than that of normal mice before 13 weeks but was comparable at 26 weeks. These findings suggest that male grt mice might need more than 13 weeks to develop mature testes.<br>

Journal

  • Experimental Animals

    Experimental Animals 56 (5), 393-397, 2007

    Japanese Association for Laboratory Animal Science

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