Preclinical Cushing's Syndrome Resulting from Adrenal Black Adenoma Diagnosed with Diabetic Ketoacidosis

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  • KAHARA Toshio
    Department of Internal Medicine, Toyama Prefectural Central Hospital
  • SETO Chikashi
    Department of Urology, Toyama Prefectural Central Hospital
  • UCHIYAMA Akio
    Department of Pathology, Toyama Prefectural Central Hospital
  • USUDA Daisuke
    Department of Internal Medicine, Toyama Prefectural Central Hospital
  • AKAHORI Hiroshi
    Department of Internal Medicine, Toyama Prefectural Central Hospital
  • TAJIKA Eiji
    Department of Urology, Toyama Prefectural Central Hospital
  • MIWA Atsuo
    Department of Pathology, Toyama Prefectural Central Hospital
  • USUDA Rika
    Department of Internal Medicine, Toyama Prefectural Central Hospital
  • SUZUKI Takashi
    Department of Pathology, Tohoku University School of Medicine
  • SASANO Hironobu
    Department of Pathology, Tohoku University School of Medicine

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抄録

A right adrenal tumor was incidentally discovered on abdominal computed tomography performed on a 53-year-old Japanese man, who had been hospitalized with diabetic ketoacidosis. Normal values were obtained for adrenal hormones in the morning after an overnight fast and urinary cortisol excretion after treatment of diabetic ketoacidosis with insulin. However, overnight dexamethasone administration with 1 mg or 8 mg did not completely suppress serum cortisol levels. There were no remarkable physical findings related to Cushing's syndrome. The patient was diagnosed as having preclinical Cushing's syndrome (PCS). Histological examination of the adrenalectomy specimen demonstrated adrenal black adenoma. Blood glucose levels subsequently improved after adrenalectomy, and the patient never developed adrenal insufficiency after hydrocortisone withdrawal. The patient was treated with diet therapy alone, and maintained good glycemic control. However, the patient still showed a diabetic pattern in an oral glucose tolerance test. It seems that the existence of PCS in addition to the underlying type 2 diabetes mellitus contributed to aggravation of blood glucose levels. Although there are many aspects of the natural course of PCS that have not been thoroughly elucidated, it is necessary to remain aware that a PCS patient with abnormal glucose metabolism may develop diabetic ketoacidosis by environmental agents.<br>

収録刊行物

  • Endocrine Journal

    Endocrine Journal 54 (4), 543-551, 2007

    一般社団法人 日本内分泌学会

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