A CASE OF SMALL CELL CARCINOMA OF THE BREAST

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  • 乳腺原発小細胞癌の１例

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Abstract

A 79-year-old woman had excisional biopsy of the breast tumor. The pathological diagnosis showed breast cancer and cancer cells were present on the incisional margin. In microscopic study, the tumor was composed of nests of small neoplastic cells, and had a solid proliferation. Similar to small cell carcinoma of the lung, the tumor cells had round to fusiform shape, scant of cytoplasm and comtained finely granular nuclear chromatin. As a curative operation, quadrantectomy with axillary node dissection was performed. In the histological findings, lymph node metastasis from primary tumor was found. In the mammary gland, minute invasion from primary tumor and DCIS different from primary tumor with clear nucleoli and eosinophilic cytoplasm, was found. In immunohistochemistry, the part derived from the primary tumor was positive for NCAM, but negative for synaptophisin and Chromogranin A. On the other hand, the part of DCIS was positive for NCAM and synaptophisin, but negative for Chromogranin A. We report this rare case of primary small cell carcinoma of the breast, together with a review of literatures.

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