音響外傷に関する最近の知見

• 吉田 尚弘

  東北大学大学院神経・感覚器病態学講座耳鼻咽喉・頭頸部外科学分野

• 小林 俊光

  東北大学大学院神経・感覚器病態学講座耳鼻咽喉・頭頸部外科学分野

書誌事項

タイトル別名

• Recent Findings in Acoustic Trauma
• オンキョウ ガイショウ ニ カンスル サイキン ノ チケン

抄録

Acoustic trauma remains a most important issue in technologically advanced countries. Overexposure to intense sound damages the inner ear sensory cells and can lead to temporary threshold shift (TTS) or permanent threshold shift (PTS) if exposure is sufficiently intense or prolonged. This review includes the recent findings of histological, metabolic, physiological changes after sound exposure and the proposed mechanisms for protection from acoustic injury.<br>Cats, guinea pigs and mice are widely used as experimental models for hearing research. Recently, mice have been more frequently used because their genomic information and lower degree of inter-animal variability in the response to sound exposure. Overexposure damages the cochlea in two ways, i. e. mechanical and metabolic pathways. In mice, intense exposure (over 116dB SPL 2 hours, 8kHz octave band noise) simultaneously damages the organ of corti and stria vascularis by mostly mechanical pathways. However, sound exposure (112dB SPL 2 hours, 8kHz octave band noise) damaged the organ of Corti within a week by mechanical and metabolic pathways. The first row of outer hair cells is the most vulnerable to sound. Sound exposure (100dB SPL 2 hours, 8kHz octave band noise), which showed damage to only the first row of outer hair cells in histological findings, causes 40dB PTS.<br>To prevent and protect PTS from sound exposure, some factors or reagents have been identified in animal models, 1) efferent reflex via the olivocochlear bundle (OCB); animals with a large OCB reflex are resistant to sound. 2) conditioning effect; “conditioning” the ear by pre-exposure to a moderate level, non-traumatic sound or heat stress, restraint can dramatically reduce the development of PTS by subsequent sound exposure. 3) Reactive oxygen substances (ROS) scavenger, glutathione; oxidative stress damages the tissue, while ROS scavenger can protect the ear from sound exposure. 4) blocker of glutamate, or neutrophine, 5) steroid. Some reagents have been examined in humans as clinical trial in the US.

収録刊行物

• 耳鼻咽喉科臨床

  耳鼻咽喉科臨床 100 (5), 323-331, 2007

  耳鼻咽喉科臨床学会

キーワード

• acoustic trauma
• protection
• conditioning
• reactive oxygen substance

詳細情報

• CRID: 1390282679240153856
• NII論文ID: 10020160956
• NII書誌ID: AN00107089
• DOI: 10.5631/jibirin.100.323
• ISSN: 18844545
• ISSN: 00326313
• NDL書誌ID: 8813662
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I8813662
• Web Site: https://search.jamas.or.jp/link/ui/2007224724
• 本文言語コード: ja
• データソース種別:
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  • NDL
  • Crossref
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  • KAKEN
• 抄録ライセンスフラグ: 使用不可