Experimental Infection Studies of Pasteurella pneumotropica and V-factor Dependent Pasteurellaceae for F344-rnu Rats

• HAYASHIMOTO Nobuhito

  ICLAS Monitoring Center, Central Institute for Experimental Animals

• YASUDA Masahiko

  ICLAS Monitoring Center, Central Institute for Experimental Animals

• UENO Masami

  ICLAS Monitoring Center, Central Institute for Experimental Animals

• GOTO Kazuo

  ICLAS Monitoring Center, Central Institute for Experimental Animals

• TAKAKURA Akira

  ICLAS Monitoring Center, Central Institute for Experimental Animals

抄録

To investigate the pathogenicities of P. pneumotropica (Pp) and V-factor dependent Pasteurellaceae (VFDP) in immunodeficient rats, experimental infections of F344-rnu rats were performed using 3 strains (ATCC 35149, CNP 160 and RPZ) of Pp and 4 strains (V6, V7, V8 and V9) of VFDP. Four animals per experimental group were inoculated twice on day 0 and post-inoculation day (PID) 14 with bacterial suspension intranasally. Two animals from each group were sacrificed on PID 60 and 120, and examined. In the animals inoculated with strains of Pp, sneezing was observed in some animals inoculated with strains ATCC 35149 and CNP 160 until PID 31. No clinical signs were observed in other animals. The strains were mainly isolated from the nasal cavity and trachea on PID 60, and the nasal cavity, trachea and lung on PID 120. Inflammation and necrosis of nasal cavity mucosa were observed in all animals inoculated with strains ATCC 35149 and CNP 160 in a histopathologic examination. No histopathological changes were observed in any other animal. In the animals inoculated with strains of VFDP, neither clinical disorder nor histopathological change was observed. The strains were mainly isolated from the trachea on PID 60, and from the trachea and lungs on PID 120. From these results, the pathogenicity of Pp in immunodeficient rats appears to differ by strain, and VFDP appears to be non-pathogenic in immunodeficient rats.<br>

収録刊行物

• Experimental Animals

  Experimental Animals 57 (1), 57-63, 2008

  公益社団法人 日本実験動物学会

キーワード

• pathogenicity
• <i>P. pneumotropica</i>
• rats
• V-factor dependent <i>Pasteurellaceae</i>

詳細情報

• CRID: 1390001205044909440
• NII論文ID: 130000068003
• NII論文ID: 10020177619
• NII書誌ID: AA11032321
• DOI: 10.1538/expanim.57.57
• ISSN: 18817122
• ISSN: 00075124
• ISSN: 13411357
• NDL書誌ID: 9319701
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9319701
• Web Site: http://www.jstage.jst.go.jp/article/expanim/57/1/57_1_57/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2008155504
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可