<i>Vibrio anguillarum</i> のキノロン耐性機構

DOI 機関リポジトリ Web Site 参考文献11件 オープンアクセス
  • 奥田 潤
    Graduate School of Biosphere Science, Hiroshima University
  • 金丸 俊介
    Graduate School of Biosphere Science, Hiroshima University
  • 湯浅 明彦
    Fisheries Research Institute, Tokushima Agriculture, Forestry and Fisheries Technology Support Center
  • 中岡 典義
    Ehime Prefectural Fish Disease Control Center
  • 川上 秀昌
    Ehime Prefectural Fish Disease Control Center
  • 中井 敏博
    Graduate School of Biosphere Science, Hiroshima University

書誌事項

タイトル別名
  • A Possible Mechanism of Quinolone Resistance in Vibrio anguillarum
  • Possible Mechanism of Quinolone Resistance in Vibrio anguillarum

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抄録

To study a possible quinolone resistance mechanism in Vibrio anguillarum, we examined gyrA and parC mutations among the oxolinic acid-resistant strains and laboratory-derived mutants. One point mutation only in the quinolone resistance-determining region (QRDR) of the gyrA gene was detected in one strain isolated from ayu Plecoglossus altivelis and laboratory-derived mutants with low-level resistance. On the other hand, point mutations in both the gyrA and parC QRDRs were detected in one strain isolated from ayu and a laboratory-derived mutant with high-level resistance. These results suggest that as in other Gram-negative bacteria GyrA and ParC are the primary and secondary targets, respectively, of quinolone in V. anguillarum.

収録刊行物

  • 魚病研究

    魚病研究 41 (2), 73-75, 2006

    日本魚病学会

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