Astroblastoma: Immunohistochemical and ultrastructural study of distinctive epithelial and probable tanycytic differentiation
-
- KUBOTA Toshihiko
- Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui
-
- SATO Kazufumi
- Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui
-
- ARISHIMA Hidetaka
- Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui
-
- TAKEUCHI Hiroaki
- Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui
-
- KITAI Ryuhei
- Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui
-
- NAKAGAWA Takao
- Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui
書誌事項
- タイトル別名
-
- Astroblastoma : Immunohistochemical and ultrastructural study of distinctive epithelial and probable tanycytic differentiation
この論文をさがす
抄録
We report the clinicopathological findings of astroblastoma found in an 8-year-old girl who was subsequently treated for 11 years. The primary superficially circumscribed tumor was located in the frontoparietal lobe, while the recurrent and the second recurrent tumor were restricted to the same region 11 years later. The tumors obtained on these three occasions showed fundamentally the same histological, immunohistochemical and fine structural features. They exhibited astrocytic as well as ependymal tanycytic features with apparent epithelial cell lineage. The tumor cells showed typical features of astroblastoma comprising prominent perivascular pseudorosettes with remarkable vascular sclerosis. The immunohistochemical study revealed intensive positivity of GFAP, vimentin, epithelial membrane antigen (EMA), cytokeratin, connexin 26 and 32, desmocollin 1 and neuronal cadherin. The fine structure revealed divergent types of junctional complexes, some of which were connected with tonofilament bundles. Numerous microvilli protruded and basal lamina abutted on the tumor cell surface. We report these unique histological features, and stress that astroblastoma should be categorized as a specific type of neuroepithelial tumor.
収録刊行物
-
- Neuropathology : official journal the Japanese Society of Neuropathology
-
Neuropathology : official journal the Japanese Society of Neuropathology 26 (1), 72-81, 2006-02-01
Blackwell Publishing
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1572261550446675072
-
- NII論文ID
- 10020387417
-
- NII書誌ID
- AA11009964
-
- ISSN
- 09196544
-
- 本文言語コード
- en
-
- データソース種別
-
- CiNii Articles