Activin or Follistatin: Which is More Beneficial to Support Liver Regeneration After Massive Hepatectomy?

DOI Web Site 被引用文献5件 参考文献29件
  • ENDO Daisuke
    Institute for Molecular and Cellular Regulation, Gunma University Division of Hepato-Billiary-Pancreatic Surgery, Graduate School of Medicine, University of Tokyo
  • MAKU-UCHI Masatoshi
    Division of Hepato-Billiary-Pancreatic Surgery, Graduate School of Medicine, University of Tokyo
  • KOJIMA Itaru
    Institute for Molecular and Cellular Regulation, Gunma University

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The present study was conducted to compare the effects of exogenous follistatin and activin A on liver regeneration in 90% hepatectomized rats. Intraportal administration of follistatin markedly accelerated liver regeneration, and nuclear BrdU labeling and liver regeneration rate were greatly increased by follistatin. In contrast, administration of activin A attenuated liver regeneration. After 120 h of 90% hepatectomy, histological analysis showed that the hepatic architecture was restored in control and activin-treated rats. However, it was not restored in follistatin-treated rats. The serum bilirubin levels were significantly increased in follistatin-treated rats, and the serum glucose level was significantly lower in follistatin-treated rats. Although follistatin markedly accelerated liver regeneration, it reduced the function of the remnant liver. Treatment with activin A instead may be beneficial to support liver regeneration after massive hepatectomy.<br>

収録刊行物

  • Endocrine Journal

    Endocrine Journal 53 (1), 73-78, 2006

    一般社団法人 日本内分泌学会

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