Failure to Find an Association between CD14-159C/T Polymorphism and Asthma: A Family-based Association Test and Meta-analysis

• Nishimura Fumichika

  Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba

• Shibasaki Masanao

  Department of Pediatrics, Tsukuba College of Technology

• Ichikawa Kunio

  Tsukuba Memorial Hospital

• Arinami Tadao

  Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba

• Noguchi Emiko

  Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba

抄録

Background: CD14 is an essential component of the receptor for lipopolysaccharide (LPS) . LPS stimulates T-helper type 1 (Th1) cytokine expression, potentially suppressing Th2 immune responses involved in IgE-mediated allergic diseases. Previous studies have reported that -159C/T, a promoter polymorphism of CD14, is associated with total serum IgE levels and atopy, but other studies have shown conflicting results.<br> Methods: To examine possible associations of CD14 polymorphisms with asthma susceptibility, we performed transmission disequilibrium tests (TDTs) of 137 Japanese families identified through children with atopic asthma.<br> Results: We found no association between -159C/T polymorphism and asthma (p= 0.37). Quantitative TDT and ANOVA showed no association between the -159C/T genotype and total serum IgE levels. We also performed a meta-analysis of data from all available studies. Neither a fixed-effects model nor a random-effect model showed a significant odds ratio for the -159C/T polymorphism (p > 0.1).<br> Conclusions: Our data indicate that CD14 does not contribute substantially to susceptibility to asthma. Further studies examining both genotypes and environmental factors will be necessary to elucidate the role of CD14 in the development of allergic diseases.<br>

収録刊行物

• Allergology International

  Allergology International 55 (1), 55-58, 2006

  一般社団法人日本アレルギー学会

キーワード

• CD14
• genetics
• haplotype
• polymorphism
• transmission disequilibrium test

詳細情報

• CRID: 1390001204633886848
• NII論文ID: 130004476882
• NII論文ID: 10020557549
• NII書誌ID: AA11091750
• DOI: 10.2332/allergolint.55.55
• ISSN: 14401592
• ISSN: 13238930
• Web Site: http://api.elsevier.com/content/article/PII:S1323893015309485?httpAccept=text/xml
• Web Site: http://api.elsevier.com/content/article/PII:S1323893015309485?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2007045714
• 本文言語コード: en
• データソース種別:
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  • Crossref
  • CiNii Articles
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