Basic Study on Activation of Antioxidation Function in Some Organs of Mice by Radon Inhalation Using New Radon Exposure Device

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  • ラドン吸入試作装置によるマウス諸臓器中の抗酸化機能の亢進に関する研究
  • ラドン キュウニュウ シサク ソウチ ニ ヨル マウス ショゾウキチュウ ノ コウサンカ キノウ ノ コウシン ニ カンスル ケンキュウ

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Abstract

There are a lot of life style diseases that are related to reactive oxygen species in indications of the radon therapy, and, the further clarification of mechanism is expected. Therefore, in this study, we investigated the activation of antioxidation function in some organs of mice by radon inhalation using the new radon exposure device. It was enable that this device was the adjustments of radon concentration by changing the air flow rate to the specially processed radon source and so on. The mice were made to inhale the radon of 400Bq/m3 or 4000Bq/m3 with this device. Results show that in brain, lungs, liver, and kidney, both the activities of superoxide dismutase(SOD) and catalase increased, and lipid peroxide levels decreased. This suggests that radon inhalation enhanced the antioxidation function. These findings are important in understanding the mechanism of diseases in which radon therapy is used as treatment, and most of which are called activated oxygen-related diseases.

Journal

  • RADIOISOTOPES

    RADIOISOTOPES 57 (4), 241-251, 2008

    Japan Radioisotope Association

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