Acetyl Chloride-Mediated Synthesis of trans-2-[(Diethoxyphosphorylamino)alkyl]-4-aryl-5,5-dimethyl-1,3,2λ^5-dioxaphosphorinane-2-oxide
<I>N</I>-Phosphoramino-protected six-membered cyclic α-aminophosphonates <I>trans</I>-2-[(diethoxyphosphorylamino)alkyl]-4-aryl-5,5-dimethyl-1,3,2λ<SUP>5</SUP>-dioxaphosphorinane-2-oxide <B>4a</B>–<B>4l</B> were synthesized with the help of acetyl chloride. <SUP>31</SUP>P NMR was used to trace the reaction process. A possible reaction mechanism was proposed and the stereochemistry of the title compounds was studied. In order to confirm the structure of <B>4</B>, products <B>4f</B> and <B>4k</B> were recrystallized and determined by X-ray diffraction analysis.
- Bulletin of the Chemical Society of Japan
Bulletin of the Chemical Society of Japan 81(5), 630-635, 2008-05-15
The Chemical Society of Japan