Poly(ethylene glycol)-mediated Steric Stabilization of Complexes Formed between Negatively Charged Liposomes and Folate-conjugated Poly(amidoamine) Dendrimers in Water

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著者

    • OHORI Ryo
    • Department of Applied Chemistry, Tokyo University of Science
    • SAITO Asami
    • Department of Applied Chemistry, Tokyo University of Science

抄録

In order to develop a new supramolecular complex for use as an active drug carrier, we prepared complexes of an anionic liposome comprising poly(ethylene glycol) (PEG<SUB><I>n</I>=50</SUB>) monooleyl ether with folate-conjugated poly(amidoamine) dendrimers (FA-PAMAM). Regardless of the ratio of FA-PAMAM to liposome, the complexes were stably dispersed in water. These results suggest that the PEG chains play an important role in the dispersion stability of the supra-complexes, preventing the complexes from aggregating.

収録刊行物

  • Chemistry letters  

    Chemistry letters 37(3), 324-325, 2008-03-05 

    The Chemical Society of Japan

参考文献:  12件

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各種コード

  • NII論文ID(NAID)
    10021078652
  • NII書誌ID(NCID)
    AA00603318
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    03667022
  • データ提供元
    CJP書誌  J-STAGE 
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