Poly(ethylene glycol)-mediated Steric Stabilization of Complexes Formed between Negatively Charged Liposomes and Folate-conjugated Poly(amidoamine) Dendrimers in Water

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  • Ryo Ohori
    Department of Applied Chemistry, Tokyo University of Science
  • Katsumi Uchida
    Department of Applied Chemistry, Tokyo University of Science
  • Asami Saito
    Department of Applied Chemistry, Tokyo University of Science
  • Hirofumi Yajima
    Department of Applied Chemistry, Tokyo University of Science

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<jats:title>Abstract</jats:title> <jats:p>In order to develop a new supramolecular complex for use as an active drug carrier, we prepared complexes of an anionic liposome comprising poly(ethylene glycol) (PEGn=50) monooleyl ether with folate-conjugated poly(amidoamine) dendrimers (FA-PAMAM). Regardless of the ratio of FA-PAMAM to liposome, the complexes were stably dispersed in water. These results suggest that the PEG chains play an important role in the dispersion stability of the supra-complexes, preventing the complexes from aggregating.</jats:p>

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  • Chemistry Letters

    Chemistry Letters 37 (3), 324-325, 2008-02-16

    Oxford University Press (OUP)

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