Naphthyridine-tethered Oligodeoxyribonucleotides : Dye/DNA Conjugates for Homogeneous SNPs Assays
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We here report the synthesis and fluorescence properties of naphthyridine-tethered oligodeoxyribonucleotides for discrimination of cytosine-related single nucleotide alterations in DNA. A/C alleles of cytochrome P450 variants (CYP2C19) were successfully discriminated simply by adding baeDANP-ODN under slightly basic conditions.
- Chemistry Letters
Chemistry Letters 37(3), 354-355, 2008-03-05
The Chemical Society of Japan