Electronically Modified Polymer-supported Cinchona Phase-transfer Catalysts for Asymmetric Synthesis of α-Alkyl-α-amino Acid Derivatives
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Merrifield resin-supported hydrocinchonidinium salts containing particular functional groups that can participate in hydrogen bonding were prepared and evaluated as chiral phase-transfer catalysts using the asymmetric benzylation of glycine imine ester. These electronically modified Merrifield resin-supported phase-transfer catalysts generally provided better enantioselectivities compared to the unmodified ones.
- Chemistry Letters
Chemistry Letters 37(4), 436-437, 2008-04-05
The Chemical Society of Japan