Synthesis and Stereochemical Assignment of Angucycline Antibiotic, PD-116740
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The first total synthesis and absolute structure assignment of PD-116740 (<B>2</B>) was achieved by exploiting two key steps: 1) a thermal ring expansion of a benzocyclobutene derivative, and 2) pinacol cyclization of biaryl dialdehyde.
- Chemistry Letters
Chemistry Letters 37(4), 470-471, 2008-04-05
The Chemical Society of Japan