PEG-b-polyamine Stabilized Bionanoparticles for Nanodiagnostics and Nanotherapy
Poly(ethylene glycol)-<I>b</I>-poly(2-(<I>N</I>,<I>N</I>-dimethylamino)ethyl methacrylate) block copolymers possessing a reactive group at the PEG chain end (R-PEG-<I>b</I>-PAMA) was synthesized by two different polymerization techniques. Using R-PEG-<I>b</I>-PAMA block copolymer thus obtained, gold nanoparticles (GNPs) were prepared. The PEG-<I>b</I>-PAMA worked as not only reducing agent of aurate ions but also coordination on the obtained nanoparticle surface. The obtained GNP had controlled sizes and narrow size distributions. It is also showed extremely high dispersion stability due to the PEG tethering chains on the surface. The same strategy could be applicable to other nanoparticles such as semiconductor quantum dot and inorganic porous nanoparticles. Using PEGylated GNPs thus prepared, several applications such as molecular recognitions, siRNA release and enzyme immobilizations were carried out. The functionalities of these materials are described in this review.
- Chemistry letters
Chemistry letters 37(6), 564-569, 2008-06-05
The Chemical Society of Japan