Glucose Responsive Two-step Release of Hydrogel-immobilized Protein
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We designed a two-step-release system that enables protein release from hydrogel in response to glucose. In the system, one of the heterodimeric coiled-coil forming peptides was initially fixed to a hydrogel via a boronate–diol interaction. The peptide was specifically released from the hydrogel by externally incoming glucose. As a result, a protein immobilized in another hydrogel was librated owing to the displacement by the peptide at its hydrogel-bound coiled-coil moiety.
- Chemistry Letters
Chemistry Letters 37(6), 582-583, 2008-06-05
The Chemical Society of Japan