Cholesterol Suppresses Pressure-induced Interdigitation of Dipalmitoylphosphatidylcholine Bilayer Membrane

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著者

    • TAMAI Nobutake
    • Department of Life System, Institute of Technology and Science, The University of Tokushima
    • MATSUI Takayuki
    • Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima
    • MORIBAYASHI Nobutaka
    • Department of Biological Science and Technology, Faculty of Engineering, The University of Tokushima
    • GOTO Masaki
    • Department of Life System, Institute of Technology and Science, The University of Tokushima
    • MATSUKI Hitoshi
    • Department of Life System, Institute of Technology and Science, The University of Tokushima
    • KANESHINA Shoji
    • Department of Life System, Institute of Technology and Science, The University of Tokushima

抄録

We investigated the effect of cholesterol on the pressure-induced interdigitation of dipalmitoylphosphatidylcholine (DPPC) bilayer membrane by fluorescence technique using 6-propionyl-2-(dimethylamino)naphthalene (Prodan) as a probe. The interdigitation pressure (IP), minimum pressure required for the bilayer interdigitation, was elevated with increasing cholesterol composition (<I>C</I><SUB>ch</SUB>) up to ca. 2 mol %. Further increase of <I>C</I><SUB>ch</SUB> did not give any effect on the IP value. Finally, the interdigitation could not be observed at <I>C</I><SUB>ch</SUB>=8 mol %. Constructed pressure–<I>C</I><SUB>ch</SUB> phase diagram at 50 °C suggests that the retardation and the abolition of the interdigitation are attributable to an interference effect and eventual formation of ordered molecular orientation induced by cholesterol.

収録刊行物

  • Chemistry letters

    Chemistry letters 37(6), 604-605, 2008-06-05

    The Chemical Society of Japan

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各種コード

  • NII論文ID(NAID)
    10021081107
  • NII書誌ID(NCID)
    AA00603318
  • 本文言語コード
    ENG
  • 資料種別
    SHO
  • ISSN
    03667022
  • データ提供元
    CJP書誌  J-STAGE 
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