Iron Salt-cataltzed Multipoint Alkylation of Pyrrole with Vinyl Ketones
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Pyrrole reacted with vinyl ketones in the presence of 3 mol % of iron(II) tetrafluoroborate or alumina-supported iron(III) perchlorate to give multipoint-alkylated products in good yield. Most notably, 4,5-dialkylated 2-acetylpyrrole was obtained in good yield when 2-acetylpyrrole was allowed to react with an excess amount of vinyl ketones.
- Chemistry Letters
Chemistry Letters 37(7), 794-795, 2008-07-05
The Chemical Society of Japan