Iron Salt-cataltzed Multipoint Alkylation of Pyrrole with Vinyl Ketones
Pyrrole reacted with vinyl ketones in the presence of 3 mol % of iron(II) tetrafluoroborate or alumina-supported iron(III) perchlorate to give multipoint-alkylated products in good yield. Most notably, 4,5-dialkylated 2-acetylpyrrole was obtained in good yield when 2-acetylpyrrole was allowed to react with an excess amount of vinyl ketones.
- Chemistry letters
Chemistry letters 37(7), 794-795, 2008-07-05
The Chemical Society of Japan