中性子構造生物学 Neutron Structural Biology

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著者

    • 新村 信雄 NIIMURA Nobuo
    • 茨城大学大学院理工学研究科 Institute of Applied Beam Science, Graduate School of Science and Enjineering, Ibaraki University

抄録

Hydrogen atoms and water molecules around proteins and nucleic acids play a crucial role in many physiological functions. Neutron diffraction provides an experimental method of directly locating hydrogen atoms. (a) Since almost all the H atom positions can be identified experimentally, the geometrical details of certain types of H-bonds can be visualized and (b) as far as mechanistic implications are concerned, the identification of protonation and deprotonation states of certain important amino acid residues can be carried out. (c) The hydration structure around proteins and the hydration networks around DNA oligomers have been successfully characterized in several outstanding cases.<BR>These will open the new field beyond the folding structure of bio-macromolecules such as:<BR>1) Recognition of proteins and nucleic acids through the network structure of water molecules surrounding bio-macromolecules, and<BR>2) The nature of chemical bond in proteins and nucleic acids elucidated by the accumulation of accurate structural information of hydrogen atoms.

収録刊行物

  • 日本結晶学会誌  

    日本結晶学会誌 50(1), 72-77, 2008-02-29 

    The Crystallographic Society of Japan

参考文献:  13件

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各種コード

  • NII論文ID(NAID)
    10021085465
  • NII書誌ID(NCID)
    AN00188364
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    03694585
  • NDL 記事登録ID
    9414715
  • NDL 雑誌分類
    ZM46(科学技術--地球科学--岩石・鉱物・鉱床)
  • NDL 請求記号
    Z15-138
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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