新しい質量分析技術の法医学領域への応用 Application of New Mass Spectrometric Techniques to Legal Medicine

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著者

    • 石井 晃 ISHII Akira
    • 名古屋大学大学院医学系研究科法医・生命倫理学 Department of Legal Medicine and Bioethics, Nagoya University Graduate School of Medicine
    • 金子 理奈 KANEKO Rina
    • 藤田保健衛生大学医学部法医学教室 Department of Legal Medicine, Fujita Health University School of Medicine
    • 浜島 誠 HAMAJIMA Makoto
    • 藤田保健衛生大学医学部法医学教室 Department of Legal Medicine, Fujita Health University School of Medicine

抄録

In the fields of legal medicine and forensic toxicology, numerous drugs and poisons obtained from diverse biological specimens such as whole blood, urine, and hair need to be identified and quantified. Therefore, it is necessary to develop new methods for analysis of drugs, especially mass spectrometric methods. In this paper, we introduce three methods—surface ionization organic mass spectrometry, a combination of mass spectrometry and cryogenic oven trapping (COT), and laser spray ionization (LSI)—and their application to legal medicine. Gas chromatography/surface ionization organic mass spectrometry is very sensitive in detecting drugs containing tertiary amine residues; for Phencyclidine (PCP), its sensitivity is 20 to 1,000 times higher than that of the conventional electron ionization method. Surface ionization organic mass spectrometry is suitable for compounds containing cyclic tertiary amino side chains. COT in combination with gas chromatography has enabled detection of many volatile organic compounds (VOCs) with high sensitivity. We have succeeded in quantifying several VOCs, such as chloroform, cyanide, thinner components, ethanol, and general anesthetics in whole blood by COT; COT affords a sensitivity that is 10 to 50 times higher than that of the conventional headspace gas chromatography method. Recently, we succeeded in identifying and quantifying 15 VOCs in human whole blood with the combination of COT and mass spectrometry. LSI is a new ionization method for liquid chromatography/mass spectrometry. We have succeeded in detecting aconitine alkaloids and psychopharmaceuticals using LSI. In the infusion mode, aconitine and haloperidol were ionized with higher efficiency compared to that in the conventional electrospray mode. However, since the signals in the LSI mode are not stable, it is necessary to improve the stability of signals in the LSI mode for applying LSI to forensic toxicology.

収録刊行物

  • 質量分析 = Mass spectroscopy

    質量分析 = Mass spectroscopy 56(3), 131-138, 2008-06-01

    The Mass Spectrometry Society of Japan

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各種コード

  • NII論文ID(NAID)
    10021086864
  • NII書誌ID(NCID)
    AN0010555X
  • 本文言語コード
    JPN
  • 資料種別
    REV
  • ISSN
    13408097
  • NDL 記事登録ID
    9541350
  • NDL 雑誌分類
    ZP4(科学技術--化学・化学工業--分析化学)
  • NDL 請求記号
    Z17-213
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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