MATHEMATICAL AND COMPUTER MODELLING REGULATORY MECHANISMS FOR PROGRAMMED CELL DEATH (APOPTOSIS)

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The system for removing needless cells (programmed cell death - apopto- sis) is important in coordination of structural-functional organisation of large number of cells in an organism. Discovery of cells suicide phenomenon has allowed revising old notions about regulation mechanisms of cellular homeostasis and importance of this mechanisms disturbance during development of large number of diseases including cancer, auto-immune diseases and infection processes. Intuitive understanding activ- ity of the regulatory system connected by means of complex interaction mechanisms between positive and negative feedback loops is very difficult. Here it is necessary for- mal mathematical methods and computer tools for modelling corresponding regulatory mechanisms. This work deals with some results of the quantitative analysis of simplest regulatory mechanisms for apoptosis process based on the methods for mathematical modeling and computer simulation.

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詳細情報

  • CRID
    1390846609810472704
  • NII論文ID
    10021089572
  • NII書誌ID
    AA1150654X
  • DOI
    10.32219/isms.67.2_279
  • ISSN
    13460447
  • 本文言語コード
    en
  • データソース種別
    • JaLC
    • CiNii Articles
  • 抄録ライセンスフラグ
    使用不可

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