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- Yoshiyama Yuji
- Division of Clinical Pharmacy, Kyoritsu University of Pharmacy
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- Misaki Tomoko
- Division of Pathophysiology, Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, Kitasato University
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- Sugiyama Takashi
- Division of Pathophysiology, Center for Clinical Pharmacy and Clinical Sciences, School of Pharmaceutical Sciences, Kitasato University
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The objective of this study was to demonstrate that the chick embryo with hyperthyroidism induced by treatment with L-thyroxin (TRX) was a feasible model as an alternative to animal model and to examine the pharmacological effects of digoxin using this model. When 0.5 or 1.0µg/egg of TRX was injected into the eggs, the 16th day-chick embryos showed some characteristic changes including an increased heart rate (tachycardia), an increased relative heart weight (cardiac hypertrophy) and relative thyroid weight (thyroid hypertrophy), and an increased concentration of plasma T3 and T4. These findings suggest that TRX-treated chick embryos may be a model of the heart diseases associated with hyperthyroidism. When 50µg/egg of digoxin was injected into the TRX-treated eggs, negative chronic action reduced. This fact suggests that digoxin decreased the sensitivity to TRX in the heart of chick embryos with hyperthyroidism as well as in dog and man. In conclusion, the TRX-treated chick embryos may prove to be an alternative to animal experiments to predict unexpected effects of cardiovascular drugs.
収録刊行物
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- Alternatives to Animal Testing and Experimentation
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Alternatives to Animal Testing and Experimentation 11 (2), 105-111, 2005
日本動物実験代替法学会
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詳細情報 詳細情報について
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- CRID
- 1390001205233851392
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- NII論文ID
- 130004556167
- 10021094603
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- NII書誌ID
- AA11161787
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- ISSN
- 21854726
- 13440411
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可