Replacement, Reduction and Refinement in the Production and Quality Control of Immunobiologicals

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This review paper will discuss some of the opportunities for three Rs approaches in the production and quality control of immunobiologicals. Major products in terms of animal use are the polyclonal antibodies(Pab), monoclonal antibodies (Mab) and vaccines. These categories of products are also characterized by the high percentage of experimental procedures that involve substantial pain and suffering to the animals. Nowadays a wide range of approaches and test methods are available that are able to substantially refine, reduce and replace animal use. These include for instance the use of humane endpoints, replacement of challenge procedures in vaccine potency testing by serological approaches or the replacement of ascites production in Mab production by <i>in vitro</i> techniques. Although total replacement of animals for production and quality control of immunobiologicals will not be possible within the near future, it is concluded that substantial three R's progress can be made quite easily without the need for exorbitant human and financial resources.

収録刊行物

  • Alternatives to animal testing and experimentation : AATEX  

    Alternatives to animal testing and experimentation : AATEX 11(3), 155-161, 2006-03-30 

    Japanese Society for Alternative to Animal Experiments

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各種コード

  • NII論文ID(NAID)
    10021094741
  • NII書誌ID(NCID)
    AA11161787
  • 本文言語コード
    ENG
  • 資料種別
    REV
  • ISSN
    13440411
  • データ提供元
    CJP書誌  J-STAGE 
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