Neurotoxicity of aluminum hydroxyl polymer on primary cultured neurons of rat cerebral cortex

DOI Web Site 参考文献10件
  • Konoha Keiko
    Department of Analytical Chemistry, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
  • Nagata Tetsuya
    Department of Analytical Chemistry, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
  • Sadakane Yutaka
    Department of Analytical Chemistry, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare
  • Kawahara Masahiro
    Department of Analytical Chemistry, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare

この論文をさがす

抄録

Aluminum(Al)is the 3rd most abundant on the earth. However, it is not essential and harmful to life beings. Al has been suspected to have a relation with various neurodegenerative diseases. The increased concentration of Al in the soil is implicated in the death of plants or fishes caused by acid rain. The toxic effects of Al are largely influenced by its chemical speciation; the concentration and the type of ligands coexist. Polynuclear hydroxy-aluminum complexes such as aluminum tridecamer(Al13; [AlO4Al12(OH)24(H2O)12]7+)is formed in the water under partially neutralization, and is more toxic in the growth of plant roots compared to monomeric Al3+ ion. In this study, we investigated the formation and the stability of Al13 using 27Al-NMR and developed a pulse-exposure method to apply chemically-identified Al13 to primary cultured neurons of rat cerebral cortex. After 14 days of the exposure at 1 h, Al13-intoxicated neurons exhibited significant decrease in cell viability. Meanwhile, monomeric Al3+ did not cause significant cell death. Our results will aid for the understanding the molecular mechanism of Al neurotoxicity.

収録刊行物

参考文献 (10)*注記

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ