フッ化カドミウム静脈内単回投与後の急性有害影響(第1報) : 致死量・肝障害・腎障害・電解質異常・代謝性アシドーシス [in Japanese] Acute Harmful Effects after Single Intravenous Dose of Cadmium Fluoride in Rats (First report) : Lethal dose, severe hepatic damage, renal injury, abnormal serum electrolytes and metabolic acidosis [in Japanese]
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Cadmium fluoride(CdF<sub>2</sub>)is commonly used as an insulator for super-high-speed mass telecommunications equipment, and there is a considerable risk that industrial workers will inhale CdF<sub>2</sub> particles. Despite the possibility that acute exposure can cause harmful systemic effects, there are no studies to date that address the health consequences of acute CdF<sub>2</sub> exposure. This study therefore aimed to determine the acute lethal dose of CdF<sub>2</sub> and its effects on various target organs, including the liver and kidney. We also determined the effect of CdF<sub>2</sub> on serum electrolytes and acid-base balance. The effective lethal dose was determined and dose-response study was conducted after intravenous administration of CdF<sub>2</sub> in rats. The 24h LD<sub>50</sub> of CdF<sub>2</sub> was determined to be 3.29 mg/kg. The dose-response study used doses of 1.34, 2.67, 4.01 mg/kg CdF<sub>2</sub>. Saline or sodium fluoride solution were used for controls. Severe hepatocellular injury was induced at doses greater than 2.67 mg/kg, as demonstrated by AST and ALT activities greater than 1,500 IU/L in rats injected with a dose of 4.01 mg/kg. Acute renal failure was induced at doses greater than 2.67 mg/kg. Decreased serum Ca, increased serum K and metabolic acidosis were induced at a dose of 4.01mg/kg. It was suggested that decreased serum Ca was caused by the exposure to ionized F. CdF<sub>2</sub> has the strongest lethal and hepatic toxicity among all Cd containing compounds.
- Biomed. Res. Trace Elements
Biomed. Res. Trace Elements 18(4), 400-404, 2007-12-31
Japan Society for Biomedical Research on Trace Elements