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- Shimizu Norikazu
- Second Department of Pediatrics, Toho University School of Medicine
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- Watanabe Atsuko
- Second Department of Pediatrics, Toho University School of Medicine
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- Nakazato Junko
- Second Department of Pediatrics, Toho University School of Medicine
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- Nakamura Hiroaki
- Second Department of Pediatrics, Toho University School of Medicine
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- Inoue Misako
- Second Department of Pediatrics, Toho University School of Medicine
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- Hirai Kaoru
- Second Department of Pediatrics, Toho University School of Medicine
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- Aoki Tsugutoshi
- Second Department of Pediatrics, Toho University School of Medicine
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抄録
Wilson disease is an autosomal recessive disorder of copper metabolism characterized by hepatic and/or neurological manifestations. This biochemical features of this disease are low serum ceruloplamine levels and high urinary copper excretion. Early diagnosis is very important to improve the prognosis of this disease. However, some patients revealed atypical biochemical findings. This study presents the efficacy of D-penicillamine challenge test for diagnosis of Wilson disease. Five patients and five normal controls were loaded 20mg/kg of D-penicillamine. Urinary copper / body weight(kg)ratio and/or urinary copper / creatinine ratio showed significant difference between Wilson disease patients and controls. The D-penicillamine challenge test will be useful for diagnosis of Wilson disease.
収録刊行物
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- Biomedical Research on Trace Elements
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Biomedical Research on Trace Elements 19 (1), 72-75, 2008
日本微量元素学会
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詳細情報
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- CRID
- 1390282679344492800
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- NII論文ID
- 130004456853
- 10021098055
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- NII書誌ID
- AN10423256
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- ISSN
- 18801404
- 0916717X
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- NDL書誌ID
- 9542131
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可