Efficacy of D-penicillamine Challenge Test for Diagnosis of Wilson Disease
-
- Shimizu Norikazu
- Second Department of Pediatrics, Toho University School of Medicine
-
- Watanabe Atsuko
- Second Department of Pediatrics, Toho University School of Medicine
-
- Nakazato Junko
- Second Department of Pediatrics, Toho University School of Medicine
-
- Nakamura Hiroaki
- Second Department of Pediatrics, Toho University School of Medicine
-
- Inoue Misako
- Second Department of Pediatrics, Toho University School of Medicine
-
- Hirai Kaoru
- Second Department of Pediatrics, Toho University School of Medicine
-
- Aoki Tsugutoshi
- Second Department of Pediatrics, Toho University School of Medicine
Search this article
Abstract
Wilson disease is an autosomal recessive disorder of copper metabolism characterized by hepatic and/or neurological manifestations. This biochemical features of this disease are low serum ceruloplamine levels and high urinary copper excretion. Early diagnosis is very important to improve the prognosis of this disease. However, some patients revealed atypical biochemical findings. This study presents the efficacy of D-penicillamine challenge test for diagnosis of Wilson disease. Five patients and five normal controls were loaded 20mg/kg of D-penicillamine. Urinary copper / body weight(kg)ratio and/or urinary copper / creatinine ratio showed significant difference between Wilson disease patients and controls. The D-penicillamine challenge test will be useful for diagnosis of Wilson disease.
Journal
-
- Biomedical Research on Trace Elements
-
Biomedical Research on Trace Elements 19 (1), 72-75, 2008
Japan Society for Biomedical Research on Trace Elements
- Tweet
Keywords
Details 詳細情報について
-
- CRID
- 1390282679344492800
-
- NII Article ID
- 130004456853
- 10021098055
-
- NII Book ID
- AN10423256
-
- ISSN
- 18801404
- 0916717X
-
- NDL BIB ID
- 9542131
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- CiNii Articles
-
- Abstract License Flag
- Disallowed