Selective Determination of Diphenhydramine in Compound Pharmaceutical Containing Ephedrine by Flow-Injection Electrochemiluminescence
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- ZHAO Changzhi
- Key Laboratory of Eco-chemical Engineering, Ministry of Education, College of Chemistry & Molecular Engineering, Qingdao University of Science & Technology
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- CHAI Xiaoli
- Key Laboratory of Eco-chemical Engineering, Ministry of Education, College of Chemistry & Molecular Engineering, Qingdao University of Science & Technology
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- TAO Shengchen
- Key Laboratory of Eco-chemical Engineering, Ministry of Education, College of Chemistry & Molecular Engineering, Qingdao University of Science & Technology
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- LI Minghua
- Key Laboratory of Eco-chemical Engineering, Ministry of Education, College of Chemistry & Molecular Engineering, Qingdao University of Science & Technology
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- JIAO Kui
- Key Laboratory of Eco-chemical Engineering, Ministry of Education, College of Chemistry & Molecular Engineering, Qingdao University of Science & Technology
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On the basis of the structural interactions between diphenhydramine (DPH) and ephedrine (EPH) to enhance electrochemiluminescence (ECL) intensity, a flow-injection ECL analysis of DPH in the present of EPH by utilizing tris(2,2′-bipyridine)ruthenium(II), (Ru(bpy)32+) has been reported. In the optimized experimental conditions, the linear ECL response to concentrations of DPH is from 2.00 to 40.0 µg/L with a correlation coefficient of 0.9995 and a detection limit of 1.20 µg/L. The relative standard deviation (RSD) was less than 4.6% (n = 5) and the recovery was in the range of 98 - 106% for the determination of DPH in pharmaceutical samples. The method avoids any interference of coexistent EPH in the compounding drug without prior separation. The method has advantages over HPLC method in terms of speed and convenience, economics and safe procedure, and could be an alternative for places where HPLC equipment is not available.
収録刊行物
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- Analytical Sciences
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Analytical Sciences 24 (4), 535-538, 2008
社団法人 日本分析化学会
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詳細情報 詳細情報について
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- CRID
- 1390282679232903168
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- NII論文ID
- 10021099794
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- NII書誌ID
- AA10500785
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- ISSN
- 13482246
- 09106340
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- NDL書誌ID
- 9452350
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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