局在プラズモンを利用したバイオセンシングプラットフォーム Biosensing Platforms Based on Localized Surface Plasmons
The biosensing platforms based on Localized Surface Plasmons (LSPs) in metallic nanoparticles are reviewed. LSP biosensors probe selective binding of analyte to the surface-immobilized ligand that shows affinity to the analyte. Binding of analyte to the nanoparticle surface causes a change in the resonance condition of LSPs, resulting in a shift in absorption or scattering spectra. The LSP sensing has an advantage that the sensing can be performed without labeling using fluorescent chromophore. While the planner Surface Plasmon Resonance (SPR) biosensor is also a label-free sensing technique, the LSP sensing has advantages as follows:(1) the optical setup is flexible,(2) miniaturized sensors such as single nanoparticle sensors are possible, and (3) the sensitivity is similar to that of the SPR sensor.
レーザー研究 36(3), 134-138, 2008-03-15
The Laser Society of Japan