非対称な三次元微細構造を用いた神経細胞群間の情報伝達方向制御 Direction Control of Information Transfer between Neuronal Populations with Asymmetric Three-Dimensional Microstructure

この論文にアクセスする

この論文をさがす

著者

抄録

Information transfer among neuronal populations has directional bias. Some past studies demonstrated that microstructure can bias a direction of information transfer at a cellular level. However the transfer at a population level has been hardly controlled to date. Here, in order to control the information transfer we attempt to bias direction of neurite outgrowth of cultured neurons with a three-dimensional asymmetric microstructure. The proposed microstructure is an embossed barrier with a rectangular-triangle cross section, namely an ascending slope and vertical wall. Because of the asymmetricity, a neurite growth rate from the wall-side to slope-side is expected to be suppressed as compared with that of slope-to-wall. We fabricated the microstructure on a polystyrene substrate by hot press, simultaneously embedding line-electrodes for probing stimulation. To confirm impact of the microstructure on neurite outgrowth, and thus signal transfer direction between neuronal populations separated by the structure, we stimulated cultured neurons on the both sides of the structure. There was difference in neuronal responses to wall-side stimulation and slope-side one, demonstrating the directional characteristic of information transfer.

収録刊行物

  • 電気学会論文誌. C, 電子・情報・システム部門誌 = The transactions of the Institute of Electrical Engineers of Japan. C, A publication of Electronics, Information and System Society  

    電気学会論文誌. C, 電子・情報・システム部門誌 = The transactions of the Institute of Electrical Engineers of Japan. C, A publication of Electronics, Information and System Society 128(7), 1036-1042, 2008-07-01 

    The Institute of Electrical Engineers of Japan

参考文献:  17件

参考文献を見るにはログインが必要です。ユーザIDをお持ちでない方は新規登録してください。

各種コード

  • NII論文ID(NAID)
    10021132951
  • NII書誌ID(NCID)
    AN10065950
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    03854221
  • NDL 記事登録ID
    9563431
  • NDL 雑誌分類
    ZN31(科学技術--電気工学・電気機械工業)
  • NDL 請求記号
    Z16-795
  • データ提供元
    CJP書誌  NDL  J-STAGE 
ページトップへ