線条体における自発カルシウム濃度変化 Spontaneous calcium changes in striatal cells

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著者

    • 小山内 実 OSANAI Makoto
    • 大阪大学大学院工学研究科電気電子情報工学専攻 Division of Electrical, Electronic and Information Engineering, Graduate School of Engineering, Osaka University
    • 矢口 雄一 YAGUCHI Yuichi
    • 大阪大学大学院工学研究科電気電子情報工学専攻 Division of Electrical, Electronic and Information Engineering, Graduate School of Engineering, Osaka University
    • 山田 尚宏 [他] YAMADA Naohiro
    • 大阪大学大学院工学研究科電気電子情報工学専攻 Division of Electrical, Electronic and Information Engineering, Graduate School of Engineering, Osaka University
    • 大星 文人 OBOSHI Fumito
    • 大阪大学大学院工学研究科電気電子情報工学専攻 Division of Electrical, Electronic and Information Engineering, Graduate School of Engineering, Osaka University
    • 八木 哲也 YAGI Tetsuya
    • 大阪大学大学院工学研究科電気電子情報工学専攻 Division of Electrical, Electronic and Information Engineering, Graduate School of Engineering, Osaka University

抄録

The striatum plays an important role in linking cortical activity to basal ganglia outputs. We conducted the calcium (Ca<sup>2+</sup>) imaging to investigate the spontaneous activities of the striatum using acute slice preparations. The corticostriatal slices of rats were stained with Fura-PE3-AM. Long lasting spontaneous intracellular Ca<sup>2+</sup> ([Ca<sup>2+</sup>]<sub>i</sub>) changes, which lasted up to several hundreds seconds, were observed. The amplitudes and the intervals of the changes were variable even in a single cell. Most cells exhibited irregular frequencies, but some exhibited oscillatory features. Most of these [Ca<sup>2+</sup>]<sub>i</sub> changes were not suppressed by TTX, blocker of action potentials. The number of the active cells, which exhibited the [Ca<sup>2+</sup>]<sub>i</sub> changes, was greatly reduced by the intracellular Ca<sup>2+</sup> store depletor, thapsigargin. Therefore, the intracellular Ca<sup>2+</sup> store is likely to contribute to the [Ca<sup>2+</sup>]<sub>i</sub> transients.<br>The [Ca<sup>2+</sup>]<sub>i</sub> changes under standard ACSF and TTX showed different levels of regularity. We tested synchronization of the [Ca<sup>2+</sup>]<sub>i</sub> changes between cell pairs under the both conditions. The number of synchronized cell pairs reduced in TTX. These results suggested that TTX insensitive and slow rate [Ca<sup>2+</sup>]<sub>i</sub> changes might exert the information processing in the striatum.

収録刊行物

  • 電気学会論文誌. C, 電子・情報・システム部門誌 = The transactions of the Institute of Electrical Engineers of Japan. C, A publication of Electronics, Information and System Society  

    電気学会論文誌. C, 電子・情報・システム部門誌 = The transactions of the Institute of Electrical Engineers of Japan. C, A publication of Electronics, Information and System Society 128(7), 1050-1057, 2008-07-01 

    The Institute of Electrical Engineers of Japan

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各種コード

  • NII論文ID(NAID)
    10021132986
  • NII書誌ID(NCID)
    AN10065950
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    03854221
  • NDL 記事登録ID
    9563538
  • NDL 雑誌分類
    ZN31(科学技術--電気工学・電気機械工業)
  • NDL 請求記号
    Z16-795
  • データ提供元
    CJP書誌  CJP引用  NDL  J-STAGE 
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