書誌事項
- タイトル別名
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- Spontaneous calcium changes in striatal cells
- センジョウタイ ニ オケル ジハツ カルシウム ノウド ヘンカ
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The striatum plays an important role in linking cortical activity to basal ganglia outputs. We conducted the calcium (Ca2+) imaging to investigate the spontaneous activities of the striatum using acute slice preparations. The corticostriatal slices of rats were stained with Fura-PE3-AM. Long lasting spontaneous intracellular Ca2+ ([Ca2+]i) changes, which lasted up to several hundreds seconds, were observed. The amplitudes and the intervals of the changes were variable even in a single cell. Most cells exhibited irregular frequencies, but some exhibited oscillatory features. Most of these [Ca2+]i changes were not suppressed by TTX, blocker of action potentials. The number of the active cells, which exhibited the [Ca2+]i changes, was greatly reduced by the intracellular Ca2+ store depletor, thapsigargin. Therefore, the intracellular Ca2+ store is likely to contribute to the [Ca2+]i transients.<br>The [Ca2+]i changes under standard ACSF and TTX showed different levels of regularity. We tested synchronization of the [Ca2+]i changes between cell pairs under the both conditions. The number of synchronized cell pairs reduced in TTX. These results suggested that TTX insensitive and slow rate [Ca2+]i changes might exert the information processing in the striatum.
収録刊行物
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- 電気学会論文誌C(電子・情報・システム部門誌)
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電気学会論文誌C(電子・情報・システム部門誌) 128 (7), 1050-1057, 2008
一般社団法人 電気学会
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詳細情報
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- CRID
- 1390282679581700224
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- NII論文ID
- 10021132986
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- NII書誌ID
- AN10065950
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- ISSN
- 13488155
- 03854221
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- NDL書誌ID
- 9563538
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
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- KAKEN
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- 抄録ライセンスフラグ
- 使用不可