書誌事項
- タイトル別名
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- Developmental Changes in Spontaneous Beating Rhythm of Cardiac Myocytes in vitro Cultured with Molecular Diffusion Culture Method
- ブンシ カクサン バイヨウホウ オ モチイタ バイヨウ シンキン サイボウ ノ セイチョウ カテイ ニ オケル ジリツ ハクドウ リズム ノ ジカン ヘンカ
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To understand the detailed mechanisms of arrhythmia and its treatment methods, it is required to elucidate the mechanisms of formation and debacle of cardiac beat at a microscopic level by using appropriate in vitro models of cardiac beating. In this study, we have developed a method for an medium-exchange-free culture of rat cardiac myocytes, and carried out long-term recording of electrical activity of cardiac myocytes from postnatal rat by means of microelectrode-array (MEA) and the new culture method. Figure 6 a) ∼ f) is a series of the properties of spontaneous beating (mean beating interval, standard deviation and coefficient of variation) of cardiac myocytes cultured by conventional culture method with alternate-day medium exchange (a ∼ c) or newly developed “molecular diffusion culture” method (d ∼ f). As shown in these figures, the difference of the beating property between the individual cultures, which is observed in conventional cultures (a) ∼ c)), was dramatically reduced in the molecular diffusion cultures (d) ∼ f)). In addition, these results also indicated that there is a transient period when all of mean beating interval, standard deviation, and coefficient of variation increase transiently before the formation of stable rhythmic fast beat.
収録刊行物
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- 電気学会論文誌C(電子・情報・システム部門誌)
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電気学会論文誌C(電子・情報・システム部門誌) 128 (7), 1064-1069, 2008
一般社団法人 電気学会
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詳細情報 詳細情報について
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- CRID
- 1390001204605054208
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- NII論文ID
- 10021133030
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- NII書誌ID
- AN10065950
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- ISSN
- 13488155
- 03854221
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- NDL書誌ID
- 9563981
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可