大理石骨病（ｏｐ／ｏｐ）マウスの大腿骨骨幹中央断面部での生体アパタイト結晶の配向性分布

• 李 志旭

  大阪大学大学院工学研究科マテリアル生産科学専攻

• 中野 貴由

  大阪大学大学院工学研究科マテリアル生産科学専攻

• 豊澤 悟

  大阪大学大学院歯学研究科顎口腔病因病態制御学講座

• 田畑 泰彦

  京都大学再生医科学研究所生体材料学分野

• 馬越 佑吉

  大阪大学大学院工学研究科マテリアル生産科学専攻

書誌事項

タイトル別名

• Areal Distribution of Preferential Alignment of Biological Apatite (BAp) Crystallite on Cross-Section of Center of Femoral Diaphysis in Osteopetrotic (op/op) Mouse
• ダイリセキコツビョウ op op マウス ノ ダイタイコツ コッカン チュウオウ ダンメンブ デノ セイタイ アパタイト ケッショウ ノ ハイコウセイ ブンフ

抄録

  Osteoclasts are nearly non-existent in mutant osteopetrotic (op/op) mice due to defects in the expression of the macrophage colony-stimulating factor (M-CSF). Thus, areal distribution of the biological apatite (BAp) c-axis in a femoral cross-section of the op/op mouse was investigated using a microbeam X-ray diffraction system in order to understand the role of osteoclasts on formation of BAp preferential alignment.<br>    The incident X-ray beam was focused to 20 μm in diameter. The diffraction analysis was performed at 20 μm displacement intervals from the periosteal surface along the radial axis of the anterior portion at a cross-section of the center of the femoral diaphysis. The op/op mouse and its normal littermate used as a control were 12 weeks old.<br>    The lack of osteoclasts induces both abnormality of the skeletal system and calcification of the medullary cavity, which are typical features of osteopetrosis. Preferential alignment of the BAp c-axis in the op/op mouse always shows a lower degree than that in the control mouse, regardless of the distance from the periosteum. Moreover, areal distributions of preferential alignment of the BAp c-axis on the femoral cross-section show quite different tendencies between the op/op and control mice. The preferential alignment of BAp gradually increases towards the periosteal surface in the op/op mouse due to the intramembranous ossification, while that in the control mouse is the lowest near the cortical envelope on the cross-section. This is because the decrease in the number of osteoclasts suppresses the normal modeling, resulting in degradation of preferential alignment of the BAp c-axis as a bone quality parameter in the op/op mouse.<br>

収録刊行物

• 日本金属学会誌

  日本金属学会誌 72 (2), 85-90, 2008

  公益社団法人 日本金属学会

キーワード

• bone
• biological apatite (BAp)
• preferential alignment
• bone quality
• intramembranous ossification
• microbeam X-ray diffraction
• modeling
• osteopetrotic mouse (op/op)
• osteoclast
• osteoblast

詳細情報

• CRID: 1390001206478840064
• NII論文ID: 10021149593
• NII書誌ID: AN00187860
• DOI: 10.2320/jinstmet.72.85
• ISSN: 18806880
• ISSN: 24337501
• ISSN: 00214876
• NDL書誌ID: 9371223
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9371223
• Web Site: https://www.jstage.jst.go.jp/article/jinstmet/72/2/72_2_85/_pdf
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可