パルス電解法により作製したチタニア/水酸アパタイト複合膜の骨伝導性評価 Osteoconductivity of Titania/Hydroxyapatite Composite Films Formed Using Pulse Electrolysis

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著者

    • 黒田 健介 KURODA Kensuke
    • 名古屋大学大学院工学研究科マテリアル理工学専攻材料工学分野 Department of Materials Science & Engineering, Graduate School of Engineering, Nagoya University
    • 志津 裕信 SHIDU Hironobu
    • 名古屋大学大学院工学研究科マテリアル理工学専攻材料工学分野 Department of Materials Science & Engineering, Graduate School of Engineering, Nagoya University
    • 市野 良一 [他] ICHINO Ryoichi
    • 名古屋大学大学院工学研究科マテリアル理工学専攻材料工学分野 Department of Materials Science & Engineering, Graduate School of Engineering, Nagoya University
    • 興戸 正純 OKIDO Masazumi
    • 名古屋大学大学院工学研究科マテリアル理工学専攻材料工学分野 Department of Materials Science & Engineering, Graduate School of Engineering, Nagoya University

抄録

  Titania (TiO<sub>2</sub>)/hydroxyapatite (HAp) composite films were prepared on commercial pure titanium rods (2 mm in diameter, 5 mm in length) by anodic-cathodic pulse electrolysis in an aqueous solution consisting of 0.3 mM Ca(H<sub>2</sub>PO<sub>4</sub>)<sub>2</sub> and 0.7 mM CaCl<sub>2</sub> and pH=5.5. The electrolysis was carried out in an autoclave at 120°C for 30 min. using +8.7 V vs. Ag/AgCl sat. KCl as the anodic potential and -9.3 V as the cathodic potential, and changing the electrolysis cycle (60~600 s) and duty ratio. We obtained TiO<sub>2</sub>/HAp composite films in which fine HAp particles were uniformly dispersed on a thin TiO<sub>2</sub> layer. The coated rods were implanted in the tibiae of 10-week-old male rats. The constructs were retrieved 14 d postimplantation and examined for new bone formation and tissue response in the cancellous and cortical bone. They were compared with HAp-coated titanium rods, TiO<sub>2</sub>-coated rods (anodizing in an aqueous solution), TiO<sub>2</sub>/HAp-coated rods formed by the high temperature oxidization of specimens coated with HAp by cathodic electrolysis, and uncoated titanium rods. Fourteen days after implantation, new bone had formed on all the coated samples (HAp, TiO<sub>2</sub>, and TiO<sub>2</sub>/HAp) and noncoated titanium rods in the cancellous bone and cortical bone. In particular, TiO<sub>2</sub>/HAp composite films prepared by pulse electrolysis had very high osteoconductivity in the part of cortical bone, which resulted from a synergistic effect of HAp and TiO<sub>2</sub> on the bioactivity.<br>

収録刊行物

  • 日本金屬學會誌 = Journal of the Japan Institute of Metals  

    日本金屬學會誌 = Journal of the Japan Institute of Metals 72(5), 383-387, 2008-05-01 

    The Japan Institute of Metals

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各種コード

  • NII論文ID(NAID)
    10021150405
  • NII書誌ID(NCID)
    AN00062446
  • 本文言語コード
    JPN
  • 資料種別
    ART
  • ISSN
    00214876
  • NDL 記事登録ID
    9514484
  • NDL 雑誌分類
    ZP41(科学技術--金属工学・鉱山工学)
  • NDL 請求記号
    Z17-314
  • データ提供元
    CJP書誌  NDL  J-STAGE 
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