Osteoconductivity of Titania/Hydroxyapatite Composite Films Formed Using Pulse Electrolysis

• Kuroda Kensuke

  Department of Materials Science & Engineering, Graduate School of Engineering, Nagoya University

• Shidu Hironobu

  Department of Materials Science & Engineering, Graduate School of Engineering, Nagoya University

• Ichino Ryoichi

  Department of Materials Science & Engineering, Graduate School of Engineering, Nagoya University

• Okido Masazumi

  Department of Materials Science & Engineering, Graduate School of Engineering, Nagoya University

• Seki Azusa

  Hamri Co., Ltd.

Bibliographic Information

Other Title

• パルス電解法により作製したチタニア／水酸アパタイト複合膜の骨伝導性評価
• パルス デンカイホウ ニ ヨリ サクセイシタ チタニア スイサン アパタイト フクゴウマク ノ コツ デンドウセイ ヒョウカ

Abstract

  Titania (TiO₂)/hydroxyapatite (HAp) composite films were prepared on commercial pure titanium rods (2 mm in diameter, 5 mm in length) by anodic-cathodic pulse electrolysis in an aqueous solution consisting of 0.3 mM Ca(H₂PO₄)₂ and 0.7 mM CaCl₂ and pH=5.5. The electrolysis was carried out in an autoclave at 120°C for 30 min. using +8.7 V vs. Ag/AgCl sat. KCl as the anodic potential and -9.3 V as the cathodic potential, and changing the electrolysis cycle (60~600 s) and duty ratio. We obtained TiO₂/HAp composite films in which fine HAp particles were uniformly dispersed on a thin TiO₂ layer. The coated rods were implanted in the tibiae of 10-week-old male rats. The constructs were retrieved 14 d postimplantation and examined for new bone formation and tissue response in the cancellous and cortical bone. They were compared with HAp-coated titanium rods, TiO₂-coated rods (anodizing in an aqueous solution), TiO₂/HAp-coated rods formed by the high temperature oxidization of specimens coated with HAp by cathodic electrolysis, and uncoated titanium rods. Fourteen days after implantation, new bone had formed on all the coated samples (HAp, TiO₂, and TiO₂/HAp) and noncoated titanium rods in the cancellous bone and cortical bone. In particular, TiO₂/HAp composite films prepared by pulse electrolysis had very high osteoconductivity in the part of cortical bone, which resulted from a synergistic effect of HAp and TiO₂ on the bioactivity.<br>

Journal

• Journal of the Japan Institute of Metals and Materials

  Journal of the Japan Institute of Metals and Materials 72 (5), 383-387, 2008

  The Japan Institute of Metals and Materials

Keywords

• hydroxyapatite
• titania
• composite coating
• pulse electrolysis
• anodizing
• hydroprocess

Details

• CRID: 1390001206479816832
• NII Article ID: 10021150405
• NII Book ID: AN00187860
• DOI: 10.2320/jinstmet.72.383
• COI: 1:CAS:528:DC%2BD1cXnvVentrk%3D
• ISSN: 18806880
• ISSN: 24337501
• ISSN: 00214876
• NDL BIB ID: 9514484
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I9514484
• Web Site: https://www.jstage.jst.go.jp/article/jinstmet/72/5/72_5_383/_pdf
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed